Adaptive Immunity

Aerobic Respiration

Note Packet

Lesson

Topic

Statement(s) and Objective(s)

Activities

1	Mitochondria	8.2.U12: The structure of the mitochondria is adapted to the function it performs Outline how mitochondria structure could evolve through natural selection. State evidence that suggests mitochondria were once free living prokaryotes. 8.2.S2: Annotations of a diagram of mitochondria to indicate the adaptations to its function Draw and label a diagram of the mitochondria. State the function of the following mitochondrial structures: outer membrane, inner membrane, cristae, intermembrane space, matrix, ribosome and mtDNA.. 8.2.A1: Electron tomography used to produce images of active mitochondria State that electron tomography enables scientists to view the dynamic nature of mitochondrial membranes.	Mitochondria handwritten notes Reading: mitochondria gone bad (questions) Info about some mitochondrial diseases Moms’ mitochondria may refresh cells in sick kids
2	Review glycolysis and Linking Reaction	8.2.U5: In aerobic cell respiration pyruvate is decarboxylated and oxidized Define decarboxylation and oxidation. 8.2.U6: In the link reaction pyruvate is converted into acetyl coenzyme A. Summarize the reactant and products of the link reaction.	Energy metabolism 1 (vision learning) Scitable: cell respiration Review respiration slides Glycolysis and linking handwritten notes Linking rxn model Why is Patrick Paralyzed Case study Respiration as a combustion reaction lab
3	Kreb’s Cycle	8.2.U7: In the Krebs cycle, the oxidation of acetyl groups is coupled to the reduction of electron carriers, liberating carbon dioxide State that NADH and FADH2 are electron carriers formed during the Krebs cycle. Outline the events of the Krebs cycle, referencing the formation of NADH and FADH2, formation of ATP and decarboxylation of acetyl groups. 8.2.S1: Analysis of diagrams of the pathways of aerobic respiration to decide where decarboxylation and oxidation reactions occur. State that decarboxylation of glucose occurs in the linking reaction and Krebs cycle of aerobic respiration.	Kreb’s cycle slides Krebs cycle handwritten notes Krebs cycle model Krebs puzzle
4	Electron Transport Chain	8.2.U8: Energy released by oxidation reactions is carried to the cristae of the mitochondria by reduced NAD and FAD State that NAD+ is reduced to become NADH in the link reaction and Krebs cycle. State that FAD is reduced to become FADH2 in the Krebs cycle. State that NADH and FADH2 carry electrons to the electron transport chain on the mitochondrial inner membrane. 8.2.U9: Transfer of the electrons between carriers in the electron transport chain in the membrane of the cristae is coupled to proton pumping. State that at the electron transport chain, FADH2 and NADH given electrons to electron carrier proteins. State that the movement of electrons through electron carrier proteins in the electron transport chain is used to pump protons (H+) across the inner mitochondrial membrane into the intermembrane space. 2.8.U4: Aerobic cell respiration requires oxygen and gives a large yield of ATP from glucose Compare the total amount of ATP made from anaerobic and aerobic respiration. State the location of aerobic respiration. 8.2.U11: Oxygen is needed to bind with the free protons to maintain the hydrogen gradient, resulting in the formation of water State that oxygen is the final electron acceptor in aerobic cellular respiration. State that that formation of water in the matrix at the end of the electron transport chain helps to maintain the hydrogen gradient between the intermembrane space and the matrix.	ETC and chemiosmosis slides ETC and chemiosmosis handwritten ETC and chemiosmosis video Model of ETC and chemiosmosis ETC and chemiosmosis game Energy metabolism II (vision learning) Cyanide case study
5	Chemiosmosis	8.2.U10: In chemiosmosis protons diffuse through ATP synthase to generate ATP. Define oxidative phosphorylation and chemiosmosis. 8.2.NOS: Paradigm shift-chemiosmotic theory led to a paradigm shift in the field of bioenergetics. Peter Mitchell’s proposal of the chemiosmotic hypothesis in 1961 lead to a major shift in our understanding of cellular processes.	ATP from “The Big Picture” Sean Carroll Chemiosmosis experiment video Chemiosmosis experiment slides
6	Experiments	2.8.S1: Analysis of results from experiments involving measurement of respiration rates in germinating seeds or invertebrates using a respirometer Outline the use of a respirometer to measure cellular respiration rate. 2.8.NOS: Assessing the ethics of scientific research- the use of invertebrates in respirometers experiments List ethical questions that must be considered before using animals in experiments.	Respirometer handwritten notes Respiration virtual lab and data Rate of respiration DBQ Vernier O2 probe Vernier CO2 probe Vernier pressure probe
7	Wrap Up and Review		Role play (need to update formatting) Another role play idea Virtual labeling activity Review questions Review form Respiration booklet notes Respiration one page summary Final knowledge audit Kahoot review 1